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Biochemistry and Microbiology


  • Kilian G, Davids H & Milne PJ (2013) Anticancer activity of the liposome-encapsulated cyclic dipeptides, cyclo(His-Gly) and cyclo(His-Ala), Pharmazie, 68(3):207-11.
  • Venables L, Koekemoer T, Sowemimo AA, Goosen ED & Van de Venter M.  (2013)  Caspase-dependent apoptosis is induced by Artemisia afra Jacq. ex Willd in a mitochondria-dependent manner after G2/M arrest.  South African Journal of Botany 84: 104–109.
  • Ibrahim B, SOWEMIMO A, Venables L, Koekemoer T, van de Venter M & Odukoya O.  Antiproliferative and apoptosis inducing activity of Markhamia tomentosa leaf extract on HeLa cells.  Journal of Ethnopharmacology available online: doi.10.1016/j.jep.2013.07.040.
  • Oyedemi S, Koekemoer T, Bradley G, van de Venter M & Afolayan A.  (2013)  In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (Gilg).  International Journal of Diabetes in Developing Countries 33(2): 120-127.
  • Williams S, Roux S, Koekemoer T, van de Venter M & Dealtry G.  (2013)  Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model.  Journal of Ethnopharmacology 146: 482-489.
  • Schnablegger GE, Venables L, Koekemoer T, Sowemimo AA & van de Venter M.  Cyathula prostrata ethanol extract activates the extrinsic pathway of apoptosis in HeLa and U937 cell lines.  South African Journal of Botany accepted for publication.
  • Jabeen A, Miranda-Sayago JM, Obara B, Spencer P, Dealtry G, Hayrabedyan S, Shaikly V, Laissue P & Fernández N. (2013) Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. Biology of Reproduction, in press.
  • Ibraheem O, Botha CEJ, Dealtry G, Roux S & Bradley G. Rice sucrose transporter1 (OsSUT1) upregulation in xylem parenchyma is caused by aphid feeding on rice leaf blade vascular bundles. Plant Biology, in press.
  • Venables L, Govender S & Oosthuizen V. (2013) Heterologous expression and purification of biologically active domains 3 and 4 of human polymeric immunoglobulin receptor and its interaction with choline binding protein A of Streptococcus pneumoniae. Protein Expression and Purification 91: 207–214.



  • Davids H, Theunissen R, Chakravorty S, Mohammed R, Frost CL, van Otterlo WAL. & de Koning C. (2012) Aminonaphthoquinones as potential anti-breast cancer agents, African Journal of Pharmacy and Pharmacology,. 6(45): 3102-3112.
  • Dealtry G, Williams S, van de Venter M & Roux S. (2012) Gene regulation by Sutherlandia frutescens, a South African anti-diabetic medicinal plant, in an insulin resistant liver cell culture model of type 2 diabetes. Scientific Research and Essays 7:13-14.
  • Spencer PS, Hakam S, Laissue P, Jabeen A, Jain P, Hayrabedyan S,  Todorova K, Blanch A, McElhinney J, Muhandiram N, Alkhatib S, Dealtry G, Miranda-Sayago J & Fernández N. (2012) Key cellular components and interactive histocompatibility molecules regulating tolerance to the fetal allograft. American Journal of Reproductive Immunology 68(2): 95-99.
  • Dhladhla B, Lee M, Moore S & Dealtry G. (2012) Comparison of light microscopy and scanning electron microscopy for enumeration of Cryptophlebia leucotreta granulovirus. Microscopy Society of Southern Africa Proceedings 42, 6.
  • Dhladhla B, Dealtry G, Moore S, Lee M & Olivier E. (2012) Structural evaluation of Cryptophlebia leucotreta granulovirus by TEM. Microscopy Society of Southern Africa Proceedings 42, 26.
  • Downing S, van de Venter M & Downing TG (2012)  The Effect of Exogenous β-N-Methylamino-L-alanine on the Growth of Synechocystis PCC6803.  Environmental Microbiology 63: 149-156.
  • Sowemimo A, van de Venter M, Baatjies L, Koekemoer T, Adesanya S & Lin W.  (2012)   Cytotoxic compounds from the leaves of Combretum paniculatum Vent.  African Journal of Biotechnology 11(20): 4631-4635.
  • MacKenzie J, Koekemoer T, Roux S, van de Venter M & Dealtry G.  (2012)  Effect of Sutherlandia frutescens on the lipid metabolism in an insulin resistant rat model and 3T3-L1 adipocytes.  Phytotherapy Research 26: 1830-1837. 
  • Ibrahim B, Sowemimo A, van Rooyen A & van de Venter M.  (2012)  Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).  Journal of Ethnopharmacology. 141, 282-289.
  • Deutschländer MS, Lall N, van de Venter M & Dewanjee S.  (2012)  The hypoglycemic activity of Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark evaluated in a streptozotocin–nicotinamide induced type 2 diabetes rat model.  South African Journal of Botany 80: 9–12.
  • Bassey P, Sowemimo AA, Lasore O, Spies L & van de Venter M.  (2012)  Biological activities and nutritional value of Tapinanthus bangwensis leaves.  African Journal of Biotechnology 11(73): 13821-13826.
  • Cagri-Mehmetoglu A, Kusakli S & van de Venter M.  (2012)  Production of polysaccharide and surfactin by Bacillus subtilis ATCC 6633 using rehydrated whey powder as the fermentation medium.  Journal of Dairy Science 95: 3643-2649.
  • Boukes GJ & van de Venter M.  (2012)  Rooperol as an antioxidant and its role in the innate immune system: An in vitro study.  Journal of Ethnopharmacology 144: 692-699.
  • Govender S, Gqunta K, le Roux M, de Villiers B & Chalkley LJ. (2012) Antibiotic susceptibilities and resistance genes of Ureaplasma parvum isolated in South Africa. Journal of Antimicrobial Chemotherapy 67: 2821-2824 (doi:10.1093/jac/dks314).
  • Govender S & Chalkley LJ. (2012) Tetracycline genes of ureaplasmas. South Afr. J Epidemiol Infect 27(1): 19-23.



  • Ibraheem O, Dealtry G, Roux S & Bradley G. (2011) The Effect of Drought and Salinity on the Expressional Levels of Sucrose Transporters in Rice (Oryza sativa Nipponbare) Cultivar Plants. Plant Omics Journal 4(2):68-74.
  • Dahan-FARKAS N, Langley C, Rousseau AL, Yadav DB, Davids H & de Koning CB. (2011) 6-Substituted Imidazo[1,2-a]pyridines: Synthesis and Biological Activity Against Colon Cancer Cell Lines HT-29 and Caco-2, European Journal of Medicinal Chemistry, 46(9): 4573-4583.
  • Lourens ACU, Van Vuuren SF, Viljoen AM, Davids H & Van Heerden FR. (2011) Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species, South African Journal of Botany, 77(1): 229-235.
  • Deutschlander MS, Lall N, van de Venter M & Hussein AA.  (2011)  Hypoglycemic evaluation of a new triterpene and other compounds isolated from Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark.  Journal of Ethnopharmacology 133: 1091-1095.
  • Du Plessis-Stoman D, du Preez JGH & van de Venter M.  (2011)  Combination treatment with oxaliplatin and mangiferin causes inceased apoptosis and downregulation of NFκB in cancer cell lines.  African Journal of Traditional, Complementary and Alternative Medicine 8(2): 177-184.
  • Van Huyssteen M, Milne PJ, Campbell EE & van de Venter M.  (2011)  Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa.  African Journal of Traditional, Complementary and Alternative Medicine 8(2): 150-158.
  • Boukes GJ & van de Venter M.  (2011)  Cytotoxicity and mechanism(s) of action of Hypoxis spp. (African potato) against HeLa, HT-29 and MCF-7 cancer cell lines.  Journal of Medicinal Plants Research.  5(13): 2766-2774.
  • Sowemimo A, van de Venter M, Baatjies L & Koekemoer T.  (2011)  Cytotoxicity of selected Nigerian plants used in traditional cancer treatment.  Journal of Medicinal Plants Research 5(11): 2442-2444.
  • Bowles SL, Jaeger C, Ferrara C, Fingeroth J, Van de Venter M & Oosthuizen V.  (2011)  Comparative binding of soluble fragments (derCD23, sCD23, exCD23) of recombinant human CD23 to CD21 (SCR1-2) and native IgE, and their effect on IgE regulation.  Cellular Immunology doi: 10.1016/j.cellimm.2011.08.003.
  • Adelakun OE, Ade-Omowaye BIO, Adeyemi IA & Van de Venter M.  (2011) Mineral composition and the functional attributes of Nigerian okra seed (Abelmoschus esculentus Moench) flour.  Food Research International 47: 348-352.
  • Esterhuizen M, Pflugmacher S & Downing TG (2011) β-N-Methylamino-l-alanine (BMAA) uptake by the aquatic macrophyte Ceratophyllum demersum. Ecotoxicol Environ Saf. 04 May 2010, 0147-6513.
  • ESTERHUIZEN-LONDT M, DOWNING S & DOWNING TG (2011) Improved sensitivity using liquid chromatography mass spectrometry (LC-MS) for detection of propyl chloroformate derivatized β-N-methylamino-L-alanine (BMAA) in cyanobacteria. Water SA 37(2):133-138.
  • DOWNING TG (2011) The development of an analytical system for β-N-methylamino-L-alanine and investigation of distribution of producing organisms and extent of freshwater contamination.  WRC Report.  ISBN 978-1-4312-0060-3.
  • DOWNING TG (2011) Cyanobacteria. In: The Sustainable Water Resource Handbook, Volume 2. WR Harding and JA Thornton (Eds.) Alive2green, Cape Town, South Africa.
  • Esterhuizen M, Pflugmacher S & Downing TG (2011) The effect of beta-N-methylamino-L-alanine (BMAA) on oxidative stress response enzymes of the macrophyte Ceratophyllum demersum. Toxicon 57(5):803-810.
  • BANACK SA, METCALF JS, SPáčIL Z, DOWNING TG, Downing S, Long A, Nunn PB & Cox PA. (2011) Distinguishing the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) from other diamino acids. 57(5):730-738.
  • DOWNING S, BANACK SA, METCALF JS, COX PA & DOWNING TG (2011) Nitrogen starvation of cyanobacteria results in the production of β-N-methylamino-L-alanine. Toxicon 58:187-194.
  • PHELAN RR & DOWNING TG (2011) A growth advantage for microcystin production by Microcystis PCC780 under high light. Journal of Phycology. 47:1241–1246.
  • ESTERHUIZEN-LONDT M & DOWNING TG (2011) Solid phase extraction of β-N-methylamino-L-alanine (BMAA) from South African water supplies. Water SA 37: 523-527.



  • Shaikly V, Shakhawat A, Withey A, Morrison I, Taranissi M, Dealtry G, Jabeen A, Cherry R & Fernandez N. (2010) Cell bio-imaging reveals co-expression of HLA-G and HLA-E in human preimplantation embryos. Reproductive Biomedicine Online 20, 223-233.
  • Boukes GJ, Daniels BB, Albrecht CF & van de Venter M.  (2010)  Cell Survival or Apoptosis: Rooperol's Role as Anticancer Agent.  Oncology Research 18(8): 365-376.
  • Adelakun OE, Ade-Omowaye BIO, Adeyemi IA & van de Venter M.   (2010)  Functional properties and mineral contents of a Nigeria Okra Seed (Abelmoschus esculentus Moench) flour as influcenced by pretreatments.  Journal of Food Technology 8(2): 39-45.
  • Govender S, du Plessis SJ, van de Venter M & Hayes C.  (2010)  Antibiotic susceptibility of multi-drug resistant Mycobacterium tuberculosis using flow cytometry.  Medical Technology SA 24(2): 25-28.
  • Banack SA, Downing TG, Spácil Z, Purdie EL, Metcalf JS, Downing S, Esterhuizen M, Codd GA & Cox PA. (2010) Distinguishing the cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB). Toxicon. Nov;56(6):868-79.



  • Adebiyi AO, Koekemoer T, Adebiyi AP, Smith N, Baxter E, Naude RJ & van de Venter M.  (2009)  Antimicrobial and antioxidant activities of crude extracts of two Nigerian chewing sticks.  Pharmaceutical Biology 47, 320-327.
  • Deutschlander MS, Lall N & van de Venter M.  (2009)  Plants used in the treatment of diabetes by traditional South African healers.  Pharmaceutical Biology 47, 348-365.
  • Prinsloo E, van de Venter M, Naude RJ & Oosthuizen V.  (2009)  Biological Inferences from IgM Binding Characteristics of Recombinant Human Secretory Component Mutants.  Immunology Letters 122, 94-98.
  • Adelakun OE, Oyelade OJ, Ade-Omowaye BIO, Adeyemi AI, van de Venter M & Koekemoer T.  (2009)  Influence of pre-treatment on yield, chemical and antioxidant properties of a Nigerian Okra Seed (Abelmoschus esculentus Moench) Flour.  Food and Chemical Toxicology 47, 657-661.
  • MacKenzie J, Koekemoer T, van de Venter M, Dealtry G & Roux S.  (2009)  Sutherlandia frutescens limits the development of insulin resistance by decreasing free fatty acid levels.  Phytotherapy Research 23(11), 1609-1614.
  • Adelakun OE, Oyelade OJ, Ade-Omuwaye BIO, Adeyemi AI & van de Venter M.  (2009)  Chemical composition and the antioxidative properties of Nigerian Okra Seed (Abelmoschus esculentus Moench) Flour.  Food and Chemical Toxicology 47, 1123-1126.
  • Klos M, van de Venter M, Milne PJ, Traore HN, Meyer D & Oosthuizen V.  (2009)  In vitro anti-HIV activity of five selected South African medicinal plant extracts.  Journal of Ethnopharmacology 124: 182-188.
  • Erasto P, van de Venter M, Roux S, Grierson D & Afolayan A.  (2009)  Effect of leaf extracts of Vernonia amygdalia on glucose utilization in Chang-liver, C2C12 and 3T3-L1 cells.  Pharmaceutical Biology 47, 175-181.
  • Deutschlander M, Lall N, Roux S, Louw J & van de Venter M.  (2009)  Hypoglycaemic activity of four plant extracts traditionally used for diabetes in South Africa.  Journal of Ethnopharmacology 124: 619-624.
  • Sowemimo A, van de Venter M, Baatjies L & Koekemoer T.  (2009)  Cytotoxic activity of selected Nigerian plants.  African Journal of Traditional, Complementary and Alternative Medicine  6(4): 526-528.
  • Govender S, Theron G, Odendaal H & Chalkley L. (2009) Prevalence of genital Mycoplasmas, Ureaplasmas and Chlamydia in pregnancy. J of Obstetrics & Gynaecology 29(8):698-701.
  • HARDING WR, DOWNING TG, VAN GINKEL CE & MOOLMAN APM. (2009) An overview of cyanobacterial research and management in South Africa post-2000.  Water SA 35 (4), 479-484.
  • DU PLESSIS-STOMAN D, DOWNING TG, VAN DE VENTER M & GOVENDER S. (2009) Traditional herbal medicines: potential degradation of sterols and sterolins by microbial contaminants. South African Journal of Science 105, 147-150.