Theses and Dissertations

2008

  • Tshidino, SC. Purification and partial characterization of a myofibril-bound serine protease and its endogenous inhibitor from skeletal muscle of the ostrich. MSc Dissertation, Nelson Mandela Metropolitan University, April 2008. Spervisor: Prof RJ Naude

2007

  • DAMBUZA, NT. Isolation of bioactive metabolities with activity against HIV-1 target proteins from extracts of Sutherlandia frutescens and Lobostemon trigonus . MSc Dissertation, Nelson Mandela Metropolitan University, April 2007. Supervisor: Dr V Oosthuizen
  • DU PLESSIS-STOMAN, D. An investigation of the in vitro anticancer  properties of selected platinum compounds. MSc Dissertation, Nelson Mandela Metropolitan  University, April 2007. Supervisor: Dr M van de Venter; Co - Supervisor: Prof JGH Du Preez.
  • FERREIRA, L. Cytokine properties of CD23 on human eosinophilic cells. MSc Dissertation, Nelson Mandela Metropolitan University, April, 2007. Supervisor: Dr V Oosthuizen; Co-Supervisor: Dr M van de Venter.
  • MNONOPI, NO. In vitro testing to investigate the anticoagulant / antithrombotic  and antidiabetic biological activity of Leonotis leonurus. MSc Dissertation, Nelson Mandela Metropolitan University, April 2007. Supervisor: Dr CL Frost; Co-Supervisor: Ms R-A Levendal.
  • MONI, A. An investigation of the presence of u - and m - calpain in ostrich skeletal muscle. MSc Dissertation, Nelson Mandela Metropolitan University, April 2007. Supervisor: Dr CL Frost; Co-Supervisor: Prof RJ Naude.
  • SULEMAN, E. The role of PACC in Asperigillus flavus. MSc Dissertation, Nelson Mandela Metropolitan University, April 2007. Supervisor: Dr BM Somai.

 

2006

  • CHADWICK, WA. Metabolic effects brought about by tricyclic antidepressants and the contribution of a medicinal plant in alleviating high fat diet induced insulin resistance in male Wistar rats. PhD Thesis, Nelson Mandela Metropolitan University, April 2006. Promoter: Dr S Roux; Co-Promoters: Dr M van de Venter, Prof W Oelofsen.
  • PRINSLOO, EAG. An investigation of the binding capacities of recombinant domain mutants of the human polymeric immunoglobulin receptor (plgR). PhD Thesis, Nelson Mandela Metropolitan University, April 2006.Promoter: Dr V Oosthuizen; Co-Promoters: Dr M van de Venter, Prof RJ Naudé.
  • ASKEW, SL. Cytokine signalling functions of human soluble IgE receptors in peripheral blood mononuclear cells from normal and hyper-allergic individuals and in B- lymphoblastoid and monocytic cell lines. MSc Dissertation, Nelson Mandela Metropolitan University, April 2006. Supervisor: Dr V Oosthuizen; Co-Supervisor: Dr M van de Venter.
  • PAMBUKA, SE. Purification and partial characterization of a matrix metalloproteinase from ostrich skeletal muscle and its role in meat tenderisation. MSc Dissertation, Nelson Mandela Metropolitan University, April 2006. Supervisor: Prof RJ Naudé.
  • WILSON, GP. Optimisation of an in vitro model for anti- diabetic screening. MSc Dissertation, Nelson Mandela Metropolitan University, April 2006. Supervisor: Dr S Roux; Co-Supervisor: Dr M van de Venter.

2005

  • BUNGU, LC. Anticancer and anticoagulant activities of Tulbaghia violacea. MSc Dissertation, Nelson Mandela Metropolitan University, April 2005. Supervisor: Dr M van de Venter; Co-Supervisor: Dr CL Frost.
  • COETZEE, C. In vitro effects of Cannabis sativa on clotting and fibrinolysis of blood plasma and glucose uptake, lipolysis and differentiation of cultured cells. MSc Dissertation, Nelson Mandela Metropolitan University, April 2005.Supervisor: Dr CL Frost; Co-Supervisors: Dr M van de Venter, Ms R-A Levendal.

2004

  • BRAUNS, SCA. The effects of selected proline-based cyclic dipeptides on growth and induction of apoptosis in cancer cells. PhD Thesis, UPE, April 2004. Promoter: Dr M van de Venter; Co-Promoters: Prof RJ Naude, Prof PJ Milne
  • GEHRINGER, MM. Hepatocellular responses to microcystin-LR in Balb/c mice: detoxification, oxidative stress and gene expression. PhD Thesis, UPE, April 2004. Promoter: Prof RJ Naude
  • THOMAS, AR. Purification and characterisation of 20S proteasome from ostrich skeletal muscle and its role in meat tenderisation. PhD Thesis, UPE, April 2004. Promoter: Prof RJ Naude; Co-Promoter: Dr V Oosthuizen.
  • BOTHA, B. An investigation into the induction of oxidative stress and apoptosis by microcystin-LR in the Caco 2 cell line and intestinal tract of Balb/c mice. MSc Dissertation, UPE, April 2004. Supervisor: Ms MM Gehringer; Co-Supervisors: TG Downing, Dr M van de Venter
  • DANIELS, BB. The effect of human soluble FCeRII on the RPMI 8866 B-lymphoblastoid and U937 monocyte cell lines. MSc Dissertation, UPE, April 2004. Supervisor: Dr V Oosthuizen; Co-Supervisor: Dr M van de Venter
  • GONDOZA, H. Purification of cathepsin B and the role of cathepsins in the maturation of ostrich meat. MSc Dissertation, UPE, April 2004. Supervisor: Prof RJ Naude
  • HARNETT, SM. In vitro anti-HIV activities of Sutherlandia frutescens and Lobostemon trigonusextracts. MSc Dissertation, UPE, April 2004. Supervisor: Dr V Oosthuizen; Co-Supervisor: Dr M van de Venter

2003

  • CHADWICK, W. Observed metabolic changes in male Wistar rats after treatment with an antidepressant implied in undesirable weight gain, or Sutherlandia frutescens for Type II diabetes. MSc Dissertation, UPE, April 2003. Supervisor: Dr S Roux; Co-Supervisors: Dr M van de Venter, Prof W Oelofsen
  • COATES, N. An evaluation of the Xenopus laevis liver slice model to study the toxic effects of microcystin. MSc Dissertation, UPE, April 2003. Supervisor: Ms MM Gehringer; Co-Supervisor: TG Downing
  • GRANT, GD. The medicinal chemistry of cyclo(Trp-Trp), cyclo(Gly-Trp) and cyclo(Gly-Gly). PhD Thesis, UPE, April 2002. Promoter: Dr PJ Milne; Co-Promoter: Dr M van de Venter
  • MKWETSHANA, NT. Ostrich brain calpain I and II, and calpastatin: Purification, and kinetic and physicochemical characterization. PhD Thesis, UPE, April 2002. Promoter: Prof RJ Naude
  • DOWNS, K. The effect of selenium in the detoxification of the microcystin hepatotoxins. MSc Dissertation, UPE, April 2002. Supervisor: Ms MM Gehringer; Co-Supervisors: Prof RJ Naude, TG Downing
  • PRINSLOO, EAG. A structured mathematical model to describe the dual substrate growth of the non-heterocystous unicellular cyanobacterium Microcystis aeruginosa strain PCC 7806. MSc Dissertation, UPE, April 2002. Supervisor: TG Downing; Co-Supervisors: Ms MM Gehringer, Prof RJ Naude
  • SEMBER, CS. The effect of nutrient levels and ratios on the growth of Microcystis aeruginosaand microcystin production. MSc Dissertation, UPE, April 2002. Supervisor: TG Downing; Co-Supervisor: Dr WS Leukes
  • STRONG, PJ. The immobilization of Microcystis aeruginosa PCC 7806 on a membrane nutrient-gradostat bioreactor for the production of the secondary metabolites. MSc Dissertation, UPE, April 2002. Supervisor: TG Downing; Co-Supervisor: Dr WS Leukes